Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | JAK1 | P23458 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5168281 | 0.90 | JAK2 (0.41) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL5168143 | 0.81 | JAK2 (0.42) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL5163778 | 0.81 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL5164188 | 0.78 | SMN1; SMN2 (0.45) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL14414801 | 0.76 | ALDH1A1 (0.40) | KMT2AALDH1A1SMN1; SMN2PDE4BCYP2C19 | |
| SCHEMBL14540287 | 0.75 | JAK2 (0.42) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL29641143 | 0.73 | L3MBTL1 (0.55) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL20986848 | 0.72 | SMN1; SMN2 (0.49) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL4512387 | 0.72 | SMN1; SMN2 (0.51) | JAK2JAK1TYK2JAK3MEN1 | |
| SCHEMBL12815027 | 0.71 | SMN1; SMN2 (0.50) | JAK2JAK1TYK2JAK3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678164-B1 | SUBSTITUTED PYRAZINONE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORP (US) | 2007-04-11 | — | — | EP | disclosed |