Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 5/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14609315 | 0.95 | PDGFRA (0.44) | METAXLPDGFRAPDGFRBFGFR2 | |
| SCHEMBL1892949 | 0.86 | MET (0.57) | METAXLPDGFRAPDGFRBFGFR2 | |
| SCHEMBL12663519 | 0.85 | PDGFRA (0.51) | PDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL1891094 | 0.85 | MET (0.44) | METAXLPDGFRAPDGFRBFGFR2 | |
| SCHEMBL14540934 | 0.85 | AXL (0.43) | METAXLPDGFRAPDGFRBFGFR2 | |
| SCHEMBL1894081 | 0.84 | PDGFRA (0.55) | METAXLPDGFRAPDGFRBFGFR2 | |
| SCHEMBL1891081 | 0.82 | AXL (0.47) | METAXLPDGFRAPDGFRBFGFR2 | |
| SCHEMBL1891079 | 0.82 | FGFR2 (0.47) | METAXLPDGFRAPDGFRBFGFR2 | |
| SCHEMBL17486952 | 0.81 | PDGFRA (0.47) | METPDGFRAPDGFRBFGFR2KDR | |
| SCHEMBL14540514 | 0.80 | MET (0.45) | METAXLPDGFRAPDGFRBFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1777218-A1 | Process for the preparation of 4-phenoxy quinoline derivatives | Eisai R&D Management Co., Ltd. (JP) | 2007-04-25 | — | — | EP | disclosed |
| EP-1415987-B1 | NITROGENOUS AROMATIC RING COMPOUNDS AS ANTI CANCER AGENTS | EISAI R&D MAN CO LTD (JP) | 2007-02-28 | — | — | EP | disclosed |