Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.73 |
| ▸ | CCNA2 | P20248 | 15/20 | 0.73 |
| ▸ | CDK2 | P24941 | 15/20 | 0.73 |
| ▸ | CCNA1 | P78396 | 15/20 | 0.73 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17826802 | 0.86 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11930867 | 0.85 | CHEK1 (1.00) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14543105 | 0.84 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14541357 | 0.82 | CHEK1 (0.74) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14543052 | 0.81 | CCNA2 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542883 | 0.81 | CHEK1 (0.78) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543108 | 0.80 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL16784500 | 0.79 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413737 | 0.78 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413738 | 0.78 | CHEK1 (0.72) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069349-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-06-15 | — | — | EP | disclosed |
| EP-2069350-B1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-02-17 | — | — | EP | disclosed |
| EP-2069348-B1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-1942900-B1 | USE OF PYRAZOLO [1,5-A] PYRIMIDINE DERIVATIVES FOR INHIBITING KINASES METHODS FOR INHIBITING PROTEIN KINASES | MERCK SHARP & DOHME (US) | 2015-06-03 | — | — | EP | disclosed |
| WO-2007044441-A2 | USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |