Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 16/20 | 0.57 |
| ▸ | CDK2 | P24941 | 16/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14542953 | 0.86 | CHEK1 (0.73) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL16784486 | 0.86 | CHEK1 (0.76) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543105 | 0.84 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542883 | 0.81 | CHEK1 (0.78) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543108 | 0.80 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL16784500 | 0.79 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543052 | 0.79 | CCNA2 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413737 | 0.78 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413738 | 0.78 | CHEK1 (0.72) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL16784482 | 0.76 | CHEK1 (0.54) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069349-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2016-06-15 | — | — | EP | disclosed |