Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.77 |
| ▸ | CCNA2 | P20248 | 14/20 | 0.77 |
| ▸ | CDK2 | P24941 | 14/20 | 0.77 |
| ▸ | CCNA1 | P78396 | 14/20 | 0.77 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14542953 | 0.84 | CHEK1 (0.73) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL17826802 | 0.84 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413737 | 0.84 | CHEK1 (0.56) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542883 | 0.79 | CHEK1 (0.78) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543108 | 0.79 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL16784500 | 0.78 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543052 | 0.78 | CCNA2 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL16784482 | 0.76 | CHEK1 (0.54) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542944 | 0.76 | CHEK1 (0.60) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413738 | 0.76 | CHEK1 (0.72) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044441-A2 | USE OF PYRAZOLO [1 , 5 -A] PYRIMIDINE DERIVATIVES FOR INHIBITING PROTEIN KINASES METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |