Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12424206 | 0.84 | ALDH1A1 (0.50) | KDM4EMAP3K5OPRD1KCNH2ALDH1A1 | |
| SCHEMBL2305835 | 0.81 | KDM4E (0.55) | KDM4EMAP3K5OPRD1KCNH2ALDH1A1 | |
| SCHEMBL2757935 | 0.78 | KDM4E (0.44) | KDM4EMAP3K5OPRD1KCNH2ALDH1A1 | |
| SCHEMBL1683773 | 0.75 | KDM4E (0.48) | KDM4EMAP3K5TRPM8ALDH1A1TSHR | |
| SCHEMBL11104657 | 0.75 | KDM4E (0.48) | KDM4EMAP3K5ALDH1A1TSHRPIM1 | |
| SCHEMBL8617913 | 0.73 | — | — | |
| SCHEMBL5693351 | 0.72 | MAPK1 (0.43) | KDM4EMAP3K5OPRD1KCNH2ALDH1A1 | |
| SCHEMBL16741186 | 0.71 | ALDH1A1 (0.53) | KDM4EOPRD1KCNH2ALDH1A1L3MBTL1 | |
| SCHEMBL2568939 | 0.71 | KDM4E (0.50) | KDM4EALDH1A1MAPTTSHRRAB9A | |
| SCHEMBL28809737 | 0.71 | TSPO (0.37) | KDM4EMAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007039218-A1 | HIV INTEGRASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2007-04-12 | — | — | WO | disclosed |