Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 16/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5441915 | 0.92 | GPR119 (0.55) | OPRD1OPRK1OPRM1GPR119 | |
| SCHEMBL5367295 | 0.91 | OPRD1 (0.57) | OPRD1OPRK1OPRM1ABCB11KCNH2 | |
| SCHEMBL5954803 | 0.90 | OPRD1 (0.64) | OPRD1OPRK1OPRM1ABCB11KCNH2 | |
| SCHEMBL5218154 | 0.89 | OPRD1 (0.59) | OPRD1OPRK1OPRM1ABCB11KCNH2 | |
| SCHEMBL19598957 | 0.89 | GPR119 (0.48) | OPRD1GPR119 | |
| SCHEMBL19582851 | 0.86 | PARP14 (0.49) | GPR119 | |
| SCHEMBL4999880 | 0.86 | OPRD1 (0.54) | OPRD1OPRK1OPRM1GPR119 | |
| SCHEMBL5215770 | 0.83 | OPRD1 (0.51) | OPRD1OPRK1OPRM1ABCB11KCNH2 | |
| SCHEMBL1603972 | 0.82 | OPRD1 (0.52) | OPRD1OPRK1OPRM1KCNH2GPR119 | |
| SCHEMBL5489607 | 0.81 | GPR119 (0.57) | OPRD1OPRK1OPRM1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205317-B2 | 4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2007-04-17 | — | — | US | disclosed |