Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333565 | 0.89 | MAPT (0.37) | TLR8MAPTSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL16670954 | 0.82 | PON1 (0.31) | KDM4EKMT2A | |
| SCHEMBL31331625 | 0.78 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1KDM4E | |
| Alcohol SCHEMBL28328944 | 0.73 | MCL1 (0.33) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3922006 | 0.73 | TLR8 (0.37) | TLR8MAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6626531 | 0.72 | — | — | |
| SCHEMBL528110 | 0.71 | — | — | |
| SCHEMBL27946853 | 0.70 | CA9 (0.34) | MAPTSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL1603208 | 0.68 | ALDH1A1 (0.37) | MAPTALDH1A1KDM4E | |
| SCHEMBL6756326 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202265-B2 | Indolinone combinatorial libraries and related products and methods for the treatment of disease | SUGEN, INC. (US) | 2007-04-10 | — | — | US | disclosed |