Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14607199 | 0.90 | CDK2 (0.51) | CDK2GSK3BABL1MEN1KMT2A | |
| SCHEMBL13289337 | 0.89 | GSK3B (0.50) | CDK2GSK3BABL1AURKARPS6KB1 | |
| SCHEMBL14607200 | 0.86 | CDK2 (0.49) | CDK2GSK3BMEN1KMT2AHCRTR1 | |
| SCHEMBL12954516 | 0.85 | CDK2 (0.59) | CDK2GSK3B | |
| SCHEMBL13289304 | 0.85 | CDK2 (0.48) | CDK2GSK3BMEN1KMT2AAURKA | |
| SCHEMBL13121757 | 0.85 | CDK2 (0.60) | CDK2GSK3BHIF1AALDH1A1RAB9A | |
| SCHEMBL14301780 | 0.85 | CDK2 (0.47) | CDK2GSK3BMEN1KMT2AKDR | |
| SCHEMBL14607101 | 0.84 | GSK3B (0.50) | CDK2GSK3BABL1SMN1; SMN2 | |
| SCHEMBL12953974 | 0.84 | SIRT2 (0.40) | CDK2GSK3BMEN1KMT2AAURKA | |
| SCHEMBL13289345 | 0.83 | GSK3B (0.47) | CDK2GSK3BMEN1KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |