Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 3/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289345 | 0.96 | GSK3B (0.47) | CDK2GSK3BHIF1APTGER3MEN1 | |
| SCHEMBL13289534 | 0.95 | RET (0.48) | CDK2GSK3BHIF1ARETKDR | |
| SCHEMBL13289254 | 0.92 | CDK2 (0.47) | CDK2GSK3BMEN1KMT2AEPHB4 | |
| SCHEMBL13121757 | 0.92 | CDK2 (0.60) | CDK2GSK3BHIF1AALDH1A1RAB9A | |
| SCHEMBL13289713 | 0.91 | CDK2 (0.47) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL13289563 | 0.90 | CDK2 (0.50) | CDK2GSK3BPTGER3MEN1KMT2A | |
| SCHEMBL13289130 | 0.89 | RET (0.48) | CDK2GSK3BMEN1KMT2AAURKA | |
| SCHEMBL13289322 | 0.89 | GSK3B (0.46) | CDK2GSK3BPTGER3KMT2AALDH1A1 | |
| SCHEMBL13289245 | 0.89 | CDK2 (0.49) | CDK2GSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL12954120 | 0.89 | CDK2 (0.49) | CDK2GSK3BEPHB4AURKARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |