Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289304 | 0.96 | CDK2 (0.48) | GSK3BCDK2HIF1ARETKDR | |
| SCHEMBL13289534 | 0.94 | RET (0.48) | GSK3BCDK2HIF1ARETKDR | |
| SCHEMBL13121777 | 0.92 | CDK2 (0.59) | GSK3BCDK2 | |
| SCHEMBL13289254 | 0.92 | CDK2 (0.47) | GSK3BCDK2RETKDRMEN1 | |
| SCHEMBL13289713 | 0.92 | CDK2 (0.47) | GSK3BCDK2RETKDRMEN1 | |
| SCHEMBL13289563 | 0.89 | CDK2 (0.50) | GSK3BCDK2KDRMEN1KMT2A | |
| SCHEMBL13289130 | 0.89 | RET (0.48) | GSK3BCDK2RETKDRMEN1 | |
| SCHEMBL13289245 | 0.88 | CDK2 (0.49) | GSK3BCDK2RETKDRMEN1 | |
| SCHEMBL12954120 | 0.88 | CDK2 (0.49) | GSK3BCDK2RETKDREPHB4 | |
| SCHEMBL12954205 | 0.88 | CDK2 (0.49) | GSK3BCDK2RETKDRPTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |