Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13121528 | 0.92 | GSK3B (0.63) | GSK3BCCNE1CDK2 | |
| SCHEMBL13121521 | 0.86 | GSK3B (0.65) | GSK3BCCNE1CDK2 | |
| SCHEMBL14418844 | 0.85 | GSK3B (0.49) | GSK3BCHEK1CCNE1CDK2FAAH | |
| SCHEMBL13121549 | 0.85 | GSK3B (0.59) | GSK3BMAPTTP53CCNE1CDK2 | |
| SCHEMBL14545949 | 0.84 | GSK3B (0.60) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14418649 | 0.84 | GSK3B (0.53) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14418650 | 0.84 | GSK3B (0.61) | GSK3BCHEK1MAPTALDH1A1HTT | |
| SCHEMBL14607246 | 0.83 | GSK3B (0.53) | GSK3BCHEK1ALDH1A1CCNE1CDK2 | |
| SCHEMBL14418651 | 0.83 | GSK3B (0.55) | GSK3BCHEK1CCNE1CDK2 | |
| SCHEMBL14545947 | 0.83 | GSK3B (0.56) | GSK3BCHEK1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |