Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rezatomidine SCHEMBL7799658 | 0.84 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Rezatomidine SCHEMBL29376551 | 0.84 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Rezatomidine SCHEMBL676215 | 0.84 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Rezatomidine SCHEMBL345466 | 0.84 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL9621062 | 0.77 | GABRA1 (0.39) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL8510363 | 0.75 | GABRA1 (0.37) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3709658 | 0.75 | GABRA1 (0.37) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL8510869 | 0.75 | GABRA1 (0.37) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3749391 | 0.72 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL3418059 | 0.72 | CYP1A2 (0.45) | ADRA2AADRA2BADRA2CADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663206-B1 | 1-(2,3-DIMETHYL-PHENYL)-ETHYL-1,3-DIHYDRO-IMIDAZOLE-2-THIONE AS NON-SEDATING ALPHA 2A AGONIST | ALLERGAN INC (US) | 2007-04-04 | — | — | EP | disclosed |