Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 4/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666624 | 0.84 | MBOAT4 (0.40) | MBOAT4CLK4CCNCCDK8KCNH2 | |
| SCHEMBL3242600 | 0.80 | CYP1A2 (0.44) | MBOAT4CLK4CCNCCDK8KCNH2 | |
| SCHEMBL16532586 | 0.80 | MBOAT4 (0.43) | MBOAT4CLK4CCNCCDK8LMNA | |
| SCHEMBL3356564 | 0.80 | MBOAT4 (0.40) | MBOAT4CLK4CCNCCDK8KCNH2 | |
| SCHEMBL29478779 | 0.80 | NOTUM (0.43) | MBOAT4CLK4CCNCCDK8KCNH2 | |
| SCHEMBL30607265 | 0.80 | MBOAT4 (0.40) | MBOAT4CLK4CCNCCDK8LMNA | |
| SCHEMBL17168474 | 0.80 | MBOAT4 (0.40) | MBOAT4CLK4CCNCCDK8KCNH2 | |
| SCHEMBL481078 | 0.80 | NOTUM (0.43) | MBOAT4CLK4CCNCCDK8KCNH2 | |
| SCHEMBL18078827 | 0.80 | MBOAT4 (0.40) | MBOAT4CLK4CCNCCDK8LMNA | |
| Hydrochloric Acid SCHEMBL16517183 | 0.78 | MBOAT4 (0.42) | MBOAT4CLK4CCNCCDK8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |