Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 4/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 12/20 | 0.52 |
| ▸ | BTK | Q06187 | 10/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547887 | 0.89 | PAK4 (0.60) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL27930634 | 0.85 | PAK4 (0.64) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL14547900 | 0.84 | JAK3 (0.69) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL12085429 | 0.83 | PTK2 (0.64) | PAK4IRAK4JAK3BTKPTK2 | |
| SCHEMBL14670760 | 0.82 | SYK (0.59) | PAK4IRAK4JAK3BTKPTK2 | |
| SCHEMBL14547954 | 0.81 | PTK2 (0.60) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL14547840 | 0.81 | PAK4 (0.54) | PAK4IRAK4JAK3BTKPTK2 | |
| SCHEMBL12085425 | 0.81 | MERTK (0.66) | PAK4IRAK4JAK3BTKPTK2 | |
| SCHEMBL12082753 | 0.81 | PAK4 (0.56) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL12085327 | 0.81 | PAK4 (0.56) | PAK4IRAK4JAK3BTKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |