Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 4/20 | 0.60 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.59 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | ULK1 | O75385 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 9/20 | 0.50 |
| ▸ | BTK | Q06187 | 7/20 | 0.50 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.48 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547889 | 0.89 | PAK4 (0.60) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL27930634 | 0.82 | PAK4 (0.64) | PAK4IRAK4JAK3BTK | |
| SCHEMBL14547900 | 0.82 | JAK3 (0.69) | PAK4IRAK4JAK3BTK | |
| SCHEMBL14547954 | 0.81 | PTK2 (0.60) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL12085425 | 0.81 | MERTK (0.66) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL12085429 | 0.81 | PTK2 (0.64) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL12085351 | 0.81 | PAK4 (0.58) | PAK4IRAK4ULK1JAK3BTK | |
| SCHEMBL12085463 | 0.80 | CCNT1 (0.59) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL14547888 | 0.80 | SYK (0.62) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL14670760 | 0.80 | SYK (0.59) | PAK4IRAK4JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |