Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 4/20 | 0.64 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 13/20 | 0.50 |
| ▸ | BTK | Q06187 | 11/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547889 | 0.85 | PAK4 (0.60) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL14547900 | 0.82 | JAK3 (0.69) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL14547887 | 0.82 | PAK4 (0.60) | PAK4IRAK4JAK3BTK | |
| SCHEMBL12085425 | 0.81 | MERTK (0.66) | PAK4IRAK4JAK3BTKPTK2 | |
| SCHEMBL1019228 | 0.81 | JAK3 (0.66) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL12085351 | 0.81 | PAK4 (0.58) | PAK4IRAK4JAK3BTKTTK | |
| SCHEMBL19020702 | 0.81 | PAK4 (0.58) | PAK4IRAK4JAK3BTKHPGDS | |
| SCHEMBL12085463 | 0.81 | CCNT1 (0.59) | PAK4IRAK4JAK3BTK | |
| SCHEMBL14547888 | 0.81 | SYK (0.62) | PAK4IRAK4JAK3BTK | |
| SCHEMBL14670760 | 0.81 | SYK (0.59) | PAK4IRAK4JAK3BTKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103224497-A | Inhibitors of protein kinases | PORTOLA PHARM INC | 2013-07-31 | — | — | CN | disclosed |