Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12106446 | 0.91 | — | — | |
| SCHEMBL14548945 | 0.90 | HDAC3 (0.38) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL13772646 | 0.86 | MGAM (0.33) | TSHRMEN1MAPTKMT2AL3MBTL1 | |
| SCHEMBL12106588 | 0.85 | — | — | |
| SCHEMBL14548939 | 0.83 | MAPT (0.36) | MEN1ALDH1A1MAPTKMT2AATM | |
| SCHEMBL12956510 | 0.82 | ALDH1A1 (0.36) | TSHRALDH1A1KMT2A | |
| SCHEMBL2544830 | 0.82 | ACHE (0.31) | ACHE | |
| SCHEMBL2554064 | 0.82 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL14548937 | 0.82 | — | — | |
| SCHEMBL12106595 | 0.81 | MEN1 (0.33) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8357723-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-22 | — | — | US | disclosed |
| US-8354455-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-15 | — | — | US | disclosed |
| US-8349901-B2 | Prodrugs containing novel bio-cleavable linkers | Piramal Enterprises Limited and Apparao Satyam (IN) | 2013-01-08 | — | — | US | disclosed |