Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 4/20 | 0.31 |
| ▸ | NMT1 | P30419 | 1/20 | 0.30 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.30 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14777 | 0.87 | SLC6A2 (0.34) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12062130 | 0.86 | SLC6A2 (0.35) | KCNH2SLC6A2SLC6A4SLC6A3KIT | |
| SCHEMBL12062122 | 0.86 | KIT (0.36) | KCNH2SLC6A2SLC6A4SLC6A3KIT | |
| SCHEMBL14505 | 0.86 | SLC6A2 (0.36) | KCNH2SLC6A2SLC6A4SLC6A3KIT | |
| SCHEMBL14334 | 0.84 | SLC6A2 (0.34) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12062116 | 0.84 | SLC6A2 (0.33) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL12075845 | 0.84 | SLC6A2 (0.33) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14554 | 0.83 | SLC6A2 (0.35) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14299 | 0.83 | KIT (0.35) | KCNH2SLC6A2SLC6A4SLC6A3KIT | |
| SCHEMBL14206 | 0.83 | SLC6A2 (0.33) | KCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488525-B1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MELINTA THERAPEUTICS INC (US) | 2018-04-25 | — | — | EP | disclosed |
| US-20160031893-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | BioVersys AG (CH) | 2016-02-04 | — | — | US | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9193731-B2 | Antimicrobial compounds and methods of making and using the same | MELINTA THERAPEUTICS, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | RIB-X PHARMACEUTICALS, INC. (US) | 2012-08-30 | — | — | US | disclosed |
| WO-2011047319-A2 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220566-A1 | Antimicrobial Compounds and Methods of Making and Using the Same | MPO, LPO, CAT | KCNH2 3637/4885SLC6A2 3776/4885SLC6A4 4116/4885 |
| US-20160031893-A1 | ANTIMICROBIAL COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | MPO, LPO, CAT | KCNH2 3637/4885SLC6A2 3776/4885SLC6A4 4116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.