Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14554710 | 0.78 | PDE10A (0.53) | PRMT5WDR77PDE10A | |
| SCHEMBL12066211 | 0.76 | HCAR2 (0.48) | ALDH1A1LMNAHCAR2CYP2C9CYP2C8 | |
| SCHEMBL6798182 | 0.73 | ALDH1A1 (0.47) | TP53ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL14736660 | 0.73 | PDE10A (0.49) | MAPTPDE10A | |
| SCHEMBL14736565 | 0.72 | PDE10A (0.60) | PDE10A | |
| SCHEMBL7454315 | 0.71 | PDE10A (0.62) | PDE10A | |
| SCHEMBL17274166 | 0.71 | PDE10A (0.56) | PRMT5WDR77PDE10A | |
| SCHEMBL370295 | 0.71 | PDE10A (0.57) | PDE10A | |
| SCHEMBL14737036 | 0.71 | PDE10A (0.57) | PDE10A | |
| Hydrochloric Acid SCHEMBL14736675 | 0.70 | PDE10A (0.56) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013005798-A1 | NOVEL NITROGENATED HETEROCYCLIC RING DERIVATIVE | 持田製薬株式会社 (JP) | 2013-01-10 | — | — | WO | disclosed |