Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 8/20 | 0.68 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15723878 | 0.86 | MKNK1 (0.49) | MKNK1MKNK2CAMKK2NPC1RAB9A | |
| SCHEMBL18853950 | 0.84 | PRKCI (0.50) | MKNK1MKNK2CHEK2ARNPC1 | |
| SCHEMBL15723882 | 0.82 | MKNK1 (0.52) | MKNK1MKNK2CHEK2RIPK1NPC1 | |
| SCHEMBL15723884 | 0.82 | CYP1A2 (0.46) | MKNK1MKNK2CHEK2RIPK1KDM4E | |
| SCHEMBL15730267 | 0.81 | MKNK1 (1.00) | MKNK1MKNK2CAMKK2CHEK2RIPK1 | |
| SCHEMBL944527 | 0.79 | MKNK1 (0.42) | MKNK1MKNK2ARCDC7CDK8 | |
| SCHEMBL27914704 | 0.79 | MKNK1 (0.71) | MKNK1MKNK2CAMKK2CHEK2RIPK1 | |
| SCHEMBL28226910 | 0.79 | MKNK1 (0.76) | MKNK1MKNK2CAMKK2CHEK2RIPK1 | |
| SCHEMBL26627849 | 0.78 | USP7 (0.44) | MKNK1MKNK2RIPK1NPC1RAB9A | |
| SCHEMBL14555836 | 0.77 | MKNK1 (0.45) | MKNK1MKNK2CDC7LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194746-A1 | Compounds For the Treatment of HIV | GILEAD SCIENCES, INC. | 2018-07-12 | — | — | US | disclosed |
| US-9944619-B2 | Compounds for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2017-05-18 | — | — | US | disclosed |
| WO-2013006738-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. (US) | 2013-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180194746-A1 | Compounds For the Treatment of HIV | CCR5, NPC1, FURIN | MKNK1 2159/4885MKNK2 2342/4885CAMKK2 4642/4885 |
| US-20170137405-A1 | COMPOUNDS FOR THE TREATMENT OF HIV | CCR5, NPC1, FURIN | MKNK1 2159/4885MKNK2 2342/4885CAMKK2 4642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.