Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13754607 | 0.79 | NPC1 (0.33) | — | |
| SCHEMBL8781023 | 0.77 | ALDH1A1 (0.38) | ALDH1A1ALOX15HSD17B10GAAMEN1 | |
| SCHEMBL18201986 | 0.76 | ALOX15 (0.36) | ALDH1A1ALOX15HSD17B10GAAMEN1 | |
| Hydrochloric Acid SCHEMBL9131059 | 0.76 | ALDH1A1 (0.37) | ALDH1A1ALOX15HSD17B10GAAMEN1 | |
| SCHEMBL14283780 | 0.75 | ALOX15 (0.40) | ALDH1A1ALOX15HSD17B10GAAMEN1 | |
| SCHEMBL19975207 | 0.74 | ALDH1A1 (0.41) | ALDH1A1ALOX15HSD17B10GAAMEN1 | |
| Hydrochloric Acid SCHEMBL21173934 | 0.72 | ALDH1A1 (0.39) | ALDH1A1ALOX15HSD17B10GAAMEN1 | |
| SCHEMBL19975253 | 0.69 | ALDH1A1 (0.41) | ALDH1A1ALOX15HSD17B10GAAMEN1 | |
| SCHEMBL9737956 | 0.68 | TSHR (0.43) | ALDH1A1ALOX15HSD17B10GAAMAPT | |
| Hydrochloric Acid SCHEMBL21173925 | 0.67 | ALDH1A1 (0.39) | ALDH1A1ALOX15HSD17B10GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7192947-B2 | Peptides derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions | ASTRAZENECA AB (SE) | 2007-03-20 | — | — | US | disclosed |
| US-7192947-B2 | Peptides derivatives comprising thiazepine group for the treatment of hyperlipidemic conditions | ASTRAZENECA AB (SE) | 2007-03-20 | — | — | US | disclosed |