Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 2/20 | 0.71 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.71 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.64 |
| ▸ | WNT3A | P56704 | 1/20 | 0.62 |
| ▸ | KDM4A | O75164 | 1/20 | 0.57 |
| ▸ | KDM4B | O94953 | 1/20 | 0.57 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.55 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14558344 | 0.87 | ROCK1 (0.64) | CDK5CDK5R1WNT3AROCK1ROCK2 | |
| SCHEMBL5348176 | 0.83 | CDK5 (1.00) | CDK5CDK5R1ADORA3ROCK1RAB9A | |
| SCHEMBL5343040 | 0.83 | CYP19A1 (0.62) | CDK5CDK5R1ROCK1ROCK2RAB9A | |
| SCHEMBL5341105 | 0.80 | CDK5 (0.81) | CDK5CDK5R1ROCK1LMNAMAPT | |
| SCHEMBL5345431 | 0.80 | CDK5 (0.78) | CDK5CDK5R1ROCK1LMNANPC1 | |
| SCHEMBL19783013 | 0.80 | ADORA3 (0.78) | ADORA3KDM4AKDM4BKDM5BAGTR1 | |
| SCHEMBL5337575 | 0.78 | CYP19A1 (0.60) | CDK5CDK5R1ADORA3ROCK1ROCK2 | |
| SCHEMBL5339323 | 0.78 | LMNA (0.61) | CDK5CDK5R1ADORA3ROCK1ROCK2 | |
| SCHEMBL18997305 | 0.77 | ADORA3 (0.87) | ADORA3WNT3AKDM4AKDM4BKDM5B | |
| SCHEMBL5342327 | 0.77 | CDK5 (0.67) | CDK5CDK5R1ROCK1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |
| US-7196104-B2 | Thiazolyl urea compounds and methods of uses | AMGEN, INC. (US) | 2007-03-27 | — | — | US | disclosed |