Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEP1B | Q16820 | 11/20 | 0.54 |
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | VNN1 | O95497 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19091172 | 0.86 | MEP1B (0.53) | MEP1BKDM1AMAOAMAOBF10 | |
| SCHEMBL17788675 | 0.85 | MEP1B (0.71) | MEP1BFOLH1 | |
| SCHEMBL6911637 | 0.85 | MEP1B (0.55) | MEP1BMAOB | |
| SCHEMBL19954263 | 0.84 | MEP1B (0.48) | MEP1BKDM1AMAOAMAOBF10 | |
| SCHEMBL27119412 | 0.84 | PRSS1 (0.57) | MEP1BF10 | |
| SCHEMBL10331798 | 0.84 | MEP1B (0.54) | MEP1B | |
| SCHEMBL19954186 | 0.84 | MEP1B (0.48) | MEP1BKDM1AMAOAMAOBF10 | |
| SCHEMBL5005534 | 0.84 | MEP1B (0.52) | MEP1BKDM1AMAOAMAOB | |
| SCHEMBL23553939 | 0.83 | ROCK2 (0.60) | MEP1B | |
| SCHEMBL19287247 | 0.83 | MEP1B (0.52) | MEP1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |
| US-7189728-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING, BV (NL) | 2007-03-13 | — | — | US | disclosed |
| US-7189728-B2 | Inhibitors of dipeptidyl peptidase IV | FERRING, BV (NL) | 2007-03-13 | — | — | US | disclosed |