Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28165402 | 0.84 | NPSR1 (0.45) | KDM4EPOLBALDH1A1TSHRHTT | |
| SCHEMBL29836517 | 0.83 | KDM4E (0.56) | KDM4EPOLBALDH1A1TSHRHTT | |
| SCHEMBL28946929 | 0.82 | KDM4E (0.57) | KDM4EPOLBALDH1A1TSHRHPGD | |
| SCHEMBL29836560 | 0.82 | KDM4E (0.57) | KDM4EPOLBALDH1A1TSHRHPGD | |
| SCHEMBL28204517 | 0.81 | MAPT (0.41) | KDM4EPOLBALDH1A1TSHRHTT | |
| SCHEMBL28804680 | 0.81 | RAB9A (0.54) | KDM4EPOLBALDH1A1TSHRHTT | |
| SCHEMBL6404659 | 0.81 | HTR6 (0.56) | KDM4EPOLBALDH1A1TSHRHTT | |
| SCHEMBL14560402 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1EGFRMAPTHKDC1 | |
| SCHEMBL14560404 | 0.80 | EGFR (0.62) | KDM4EALDH1A1EGFRMAPTHKDC1 | |
| Hydrochloric Acid SCHEMBL28115890 | 0.79 | HTR6 (0.48) | KDM4EPOLBALDH1A1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |