Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 17/20 | 0.77 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14563201 | 0.88 | CTSB (0.78) | CTSKCTSB | |
| SCHEMBL14563104 | 0.88 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL14563165 | 0.88 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL14563182 | 0.88 | CTSK (0.64) | CTSKCTSB | |
| SCHEMBL14563097 | 0.87 | CTSK (0.79) | CTSKCTSB | |
| SCHEMBL14563166 | 0.87 | CTSK (0.67) | CTSKCTSB | |
| SCHEMBL14563157 | 0.87 | CTSK (0.79) | CTSKCTSB | |
| SCHEMBL14563111 | 0.87 | CTSK (0.78) | CTSKCTSB | |
| SCHEMBL14563135 | 0.87 | CTSK (0.79) | CTSKCTSB | |
| SCHEMBL2241261 | 0.87 | CTSK (1.00) | CTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170879-B1 | 1-CYANOCYCLOPROPYL-DERIVATIVES AS CATHEPSIN K INHIBITORS | ASTRAZENECA AB (SE) | 2013-01-16 | — | — | EP | claimed |