Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 16/20 | 0.53 |
| ▸ | UBA3 | Q8TBC4 | 15/20 | 0.53 |
| ▸ | SAE1 | Q9UBE0 | 5/20 | 0.53 |
| ▸ | UBA2 | Q9UBT2 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.53 |
| ▸ | GRK5 | P34947 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1795315 | 0.82 | ATG7 (0.52) | CA2 | |
| SCHEMBL17875227 | 0.81 | NAE1 (0.62) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL192379 | 0.81 | NAE1 (0.62) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL4259358 | 0.81 | TK1 (0.38) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL14563559 | 0.81 | NAE1 (0.39) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL192779 | 0.80 | NAE1 (0.61) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL17875179 | 0.80 | NAE1 (0.61) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL192708 | 0.78 | NAE1 (0.68) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL192354 | 0.77 | NAE1 (0.67) | NAE1UBA3SAE1UBA2CA2 | |
| SCHEMBL192795 | 0.77 | NAE1 (0.66) | NAE1UBA3SAE1UBA2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546256-A2 | Process for the synthesis of intermediates compounds useful for the preparation of E1 activity activating enzyme inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-01-16 | — | — | EP | disclosed |