SCHEMBL14565403

SCHEMBL14565403

C[C@H](N)C(=O)NCc1cccc(-n2nc(C(F)(F)F)cc2C(=O)Nc2cccc(S(C)(=O)=O)c2)c1

nearest known ligand 0.81

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CARM1 Q86X55 14/20 0.81
KLKB1 P03952 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14565400 0.90 CARM1 (1.00) CARM1KLKB1
SCHEMBL14565459 0.89 CARM1 (0.84) CARM1KLKB1
SCHEMBL14565455 0.88 CARM1 (0.83) CARM1KLKB1
SCHEMBL14565443 0.88 CARM1 (0.84) CARM1
SCHEMBL14565460 0.87 CARM1 (0.90) CARM1KLKB1
SCHEMBL14565458 0.87 CARM1 (0.81) CARM1KLKB1
SCHEMBL14565456 0.86 CARM1 (0.80) CARM1KLKB1
SCHEMBL14565482 0.86 CARM1 (0.80) CARM1KLKB1
SCHEMBL14565461 0.86 CARM1 (0.86) CARM1KLKB1
SCHEMBL14565465 0.86 CARM1 (0.83) CARM1KLKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070060589-A1 Inhibitors of protein arginine methyl transferases BRISTOL-MYERS SQUIBB COMPANY 2007-03-15 US disclosed
US-20070060589-A1 Inhibitors of protein arginine methyl transferases BRISTOL-MYERS SQUIBB COMPANY 2007-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070060589-A1 Inhibitors of protein arginine methyl transferases PRMT1, PRMT3, PRMT6 CARM1 20/4885KLKB1 3255/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.