Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14572004 | 0.83 | EGFR (0.40) | ALDH1A1GAAHPGDHSD17B10ALOX15 | |
| SCHEMBL28094495 | 0.74 | EGFR (0.33) | ALDH1A1PKMLMNAMAPTEGFR | |
| SCHEMBL6672123 | 0.73 | CCR1 (0.40) | ALDH1A1GAAHPGDHSD17B10USP2 | |
| SCHEMBL23869961 | 0.72 | MAP4K4 (0.47) | ALDH1A1GAAHPGDHSD17B10USP2 | |
| SCHEMBL28066391 | 0.71 | NR3C1 (0.39) | HTTKMT2AEGFR | |
| SCHEMBL14579633 | 0.71 | CHEK1 (0.44) | ALDH1A1LMNAHTTKDM4ETP53 | |
| SCHEMBL14566483 | 0.70 | IRAK4 (0.46) | ALDH1A1GAAALOX15LMNAHTT | |
| SCHEMBL5453911 | 0.70 | EGFR (0.46) | ALDH1A1HPGDHSD17B10ALOX15LMNA | |
| SCHEMBL21089732 | 0.70 | PARP1 (0.56) | ALDH1A1ALOX15CYP2C9 | |
| SCHEMBL12995259 | 0.69 | OGA (0.45) | ALDH1A1GAAHPGDHSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027855-A2 | RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2007-03-08 | — | — | WO | disclosed |