Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25519630 | 0.83 | AURKA (0.49) | CCR1CCR5CCR8HTR1AADRA1D | |
| SCHEMBL17680958 | 0.81 | CCR1 (0.44) | CCR1CCR5CCR8ALDH1A1USP2 | |
| SCHEMBL12995259 | 0.78 | OGA (0.45) | ALDH1A1GAAUSP2PKMHPGD | |
| SCHEMBL14566700 | 0.73 | ALDH1A1 (0.45) | ALDH1A1GAAUSP2PKMHPGD | |
| SCHEMBL15046641 | 0.73 | CCR1 (0.45) | CCR1CCR5CCR8ALDH1A1HPGD | |
| SCHEMBL12386875 | 0.72 | ALDH1A1 (0.51) | ALDH1A1GAAUSP2PKMHPGD | |
| SCHEMBL10496105 | 0.72 | UHRF1 (0.45) | ALDH1A1GAAUSP2PKMHPGD | |
| SCHEMBL873159 | 0.71 | HTR1A (0.58) | CCR1CCR5CCR8ALDH1A1HTR1A | |
| SCHEMBL21089732 | 0.71 | PARP1 (0.56) | ALDH1A1ALOX15FLT3ACVR1SMN1; SMN2 | |
| SCHEMBL20309118 | 0.70 | ALDH1A1 (0.53) | ALDH1A1ALOX15HSD17B10SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004026302-A1 | METHODS OF INHIBITING TGF BETA WITH SUBSTITUTED PYRAZOLES | ELI LILLY AND COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |