Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.48 |
| ▸ | MMP3 | P08254 | 15/20 | 0.35 |
| ▸ | MMP1 | P03956 | 14/20 | 0.35 |
| ▸ | MMP9 | P14780 | 9/20 | 0.35 |
| ▸ | MMP2 | P08253 | 12/20 | 0.34 |
| ▸ | MMP8 | P22894 | 4/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.34 |
| ▸ | MMP13 | P45452 | 3/20 | 0.34 |
| ▸ | MMP7 | P09237 | 4/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | MMP20 | O60882 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | MMP10 | P09238 | 1/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | MMP15 | P51511 | 1/20 | 0.33 |
| ▸ | MMP16 | P51512 | 1/20 | 0.33 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.33 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57849 | 1.00 | TUBB1 (0.48) | TUBB1MMP3MMP1MMP9MMP2 | |
| SCHEMBL13751416 | 1.00 | TUBB1 (0.48) | TUBB1MMP3MMP1MMP9MMP2 | |
| SCHEMBL13660113 | 0.90 | TUBB1 (0.43) | TUBB1MMP3MMP1MMP9MMP2 | |
| SCHEMBL13660111 | 0.86 | TUBB1 (0.57) | TUBB1MMP3MMP1MMP9MMP2 | |
| SCHEMBL6806419 | 0.86 | TUBB1 (0.57) | TUBB1MMP3MMP1MMP9MMP2 | |
| Trifluoroacetic Acid SCHEMBL6810659 | 0.81 | TUBB1 (0.53) | TUBB1MMP3MMP1MMP2ADAM17 | |
| SCHEMBL57848 | 0.80 | TUBB1 (0.41) | TUBB1MMP3MMP1MMP9MMP2 | |
| SCHEMBL14567808 | 0.80 | TUBB1 (0.41) | TUBB1MMP3MMP1MMP9MMP2 | |
| SCHEMBL22901380 | 0.78 | DPP4 (0.46) | TUBB1 | |
| SCHEMBL13660108 | 0.78 | TUBB1 (0.74) | TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633224-B2 | Hemiasterlin derivatives and uses thereof in the treatment of cancer | EISAI CO., LTD. (JP) | 2014-01-21 | — | — | US | disclosed |
| US-7192972-B2 | Hemiasterlin derivatives and uses thereof | EISAI CO., LTD. (JP) | 2007-03-20 | — | — | US | disclosed |
| US-7192972-B2 | Hemiasterlin derivatives and uses thereof | EISAI CO., LTD. (JP) | 2007-03-20 | — | — | US | disclosed |