Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.34 |
| ▸ | MMP1 | P03956 | 14/20 | 0.33 |
| ▸ | MMP3 | P08254 | 14/20 | 0.33 |
| ▸ | MMP9 | P14780 | 9/20 | 0.33 |
| ▸ | MMP2 | P08253 | 11/20 | 0.32 |
| ▸ | MMP8 | P22894 | 4/20 | 0.32 |
| ▸ | MMP13 | P45452 | 3/20 | 0.32 |
| ▸ | MMP7 | P09237 | 4/20 | 0.32 |
| ▸ | MMP14 | P50281 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 2/20 | 0.32 |
| ▸ | MMP20 | O60882 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | MMP10 | P09238 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | MMP15 | P51511 | 1/20 | 0.32 |
| ▸ | MMP16 | P51512 | 1/20 | 0.32 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.32 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14567809 | 0.90 | TUBB1 (0.48) | TUBB1ADAM17MMP1MMP3MMP9 | |
| SCHEMBL57849 | 0.90 | TUBB1 (0.48) | TUBB1ADAM17MMP1MMP3MMP9 | |
| SCHEMBL13751416 | 0.90 | TUBB1 (0.48) | TUBB1ADAM17MMP1MMP3MMP9 | |
| SCHEMBL13660111 | 0.80 | TUBB1 (0.57) | TUBB1ADAM17MMP1MMP3MMP9 | |
| SCHEMBL6806419 | 0.80 | TUBB1 (0.57) | TUBB1ADAM17MMP1MMP3MMP9 | |
| SCHEMBL6806006 | 0.80 | TUBB1 (0.50) | TUBB1ADAM17MMP1MMP9MMP14 | |
| SCHEMBL14567801 | 0.78 | TUBB1 (0.66) | TUBB1 | |
| SCHEMBL13660110 | 0.78 | TUBB1 (0.66) | TUBB1 | |
| SCHEMBL58040 | 0.78 | TUBB1 (0.66) | TUBB1 | |
| SCHEMBL57848 | 0.76 | TUBB1 (0.41) | TUBB1ADAM17MMP1MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264487-A1 | HEMIASTERLIN ANALOGS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2009-10-22 | — | — | US | disclosed |
| US-20090264487-A1 | HEMIASTERLIN ANALOGS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264487-A1 | HEMIASTERLIN ANALOGS | NUMA1, CYP11A1, PDS5A | TUBB1 168/4885ADAM17 2504/4885MMP1 4530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.