Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 6/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128423 | 0.89 | CHRM4 (0.55) | CHRM4TRPA1P2RY12TSHRHSD17B10 | |
| SCHEMBL1457667 | 0.89 | TRPA1 (0.42) | CHRM4TRPA1TRPV1 | |
| SCHEMBL1457565 | 0.88 | TRPA1 (0.42) | CHRM4TRPA1TRPV1 | |
| SCHEMBL1457623 | 0.87 | MALT1 (0.48) | TRPA1TRPV1MALT1 | |
| SCHEMBL1457138 | 0.86 | P2RY12 (0.41) | CHRM4TRPA1P2RY12TRPV1 | |
| SCHEMBL1457194 | 0.85 | TRPA1 (0.44) | TRPA1TRPV1MALT1KDM4E | |
| SCHEMBL1457424 | 0.84 | TRPA1 (0.43) | TRPA1P2RY12TRPV1MALT1 | |
| SCHEMBL1457275 | 0.84 | MALT1 (0.44) | TRPA1TRPV1MALT1 | |
| SCHEMBL5052731 | 0.84 | TRPA1 (0.46) | TRPA1TRPV1MALT1 | |
| SCHEMBL1457201 | 0.83 | TRPA1 (0.50) | TRPA1TRPV1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | claimed |
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |