Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457667 | 0.98 | TRPA1 (0.42) | TRPA1TRPV1CHRM4KCNH2TRPM8 | |
| SCHEMBL5111760 | 0.89 | CHRM4 (0.47) | TRPA1TRPV1CHRM4KCNH2TRPM8 | |
| SCHEMBL1456944 | 0.88 | CHRM4 (0.45) | TRPA1TRPV1CHRM4 | |
| SCHEMBL5125630 | 0.87 | CHRM4 (0.48) | TRPA1TRPV1CHRM4KCNH2TRPM8 | |
| SCHEMBL1457138 | 0.86 | P2RY12 (0.41) | TRPA1TRPV1CHRM4 | |
| SCHEMBL1457424 | 0.84 | TRPA1 (0.43) | TRPA1TRPV1RBP4 | |
| SCHEMBL1456795 | 0.84 | TRPA1 (0.41) | TRPA1TRPV1KCNH2TRPM8RBP4 | |
| SCHEMBL1457672 | 0.84 | TRPA1 (0.39) | TRPA1TRPV1KCNH2TRPM8RBP4 | |
| SCHEMBL1457623 | 0.83 | MALT1 (0.48) | TRPA1TRPV1KCNH2TRPM8 | |
| SCHEMBL1457194 | 0.83 | TRPA1 (0.44) | TRPA1TRPV1KCNH2TRPM8RBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | claimed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | claimed |
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |