Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14571151 | 0.87 | SGK1 (0.32) | AURKBMEN1KMT2A | |
| SCHEMBL14571148 | 0.85 | FADS1 (0.33) | GRM4LMNAALOX15RAPGEF4MAPT | |
| SCHEMBL14571081 | 0.81 | EGFR (0.34) | RAPGEF4MAP2K1 | |
| SCHEMBL4043198 | 0.81 | EGFR (0.45) | GRM4ALDH1A1LMNATDO2AURKA | |
| SCHEMBL4050643 | 0.78 | GRM4 (0.41) | GRM4ALDH1A1LMNAALOX15SMN1; SMN2 | |
| SCHEMBL4043851 | 0.78 | FBP1 (0.48) | GRM4LMNAAURKAAURKB | |
| SCHEMBL4048321 | 0.66 | EGFR (0.40) | ALDH1A1LMNAALOX15SMN1; SMN2POLB | |
| SCHEMBL4046364 | 0.66 | PDGFRB (0.48) | ALDH1A1LMNAALOX15SMN1; SMN2HPGD | |
| SCHEMBL4041829 | 0.64 | FADS1 (0.42) | GRM4LMNAALOX15SMN1; SMN2RAPGEF4 | |
| SCHEMBL4044573 | 0.64 | EGFR (0.44) | ALDH1A1LMNAAURKBPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196110-B2 | N-substituted tricyclic 3-aminopyrazoles as inhibitors for the treatment of cell proliferative disorders | JANSSEN PHAMACEUTICA N.V. (BE) | 2007-03-27 | — | — | US | disclosed |