Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 9/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457414 | 0.90 | TACR1 (0.41) | — | |
| SCHEMBL1457507 | 0.86 | MEN1 (0.42) | MEN1KMT2AL3MBTL1CYP2C19 | |
| SCHEMBL6410873 | 0.86 | ATM (0.43) | NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL1457514 | 0.85 | MEN1 (0.41) | MEN1KMT2AL3MBTL1CYP2C19 | |
| Hydrochloric Acid SCHEMBL6419339 | 0.85 | ATM (0.42) | NPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL1457747 | 0.82 | SMN1; SMN2 (0.38) | EPHX2MEN1KMT2A | |
| SCHEMBL12825008 | 0.82 | EPHX2 (0.47) | EPHX2NR1H4MEN1KMT2ANPC1 | |
| SCHEMBL1457277 | 0.82 | ALDH1A1 (0.49) | EPHX2MEN1KMT2ACYP1A2CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL5121432 | 0.81 | EPHX2 (0.47) | EPHX2NR1H4MEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL5119487 | 0.81 | EPHX2 (0.46) | EPHX2NR1H4MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |
| EP-1893620-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006122769-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | disclosed |