Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457507 | 0.93 | MEN1 (0.42) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL1457514 | 0.92 | MEN1 (0.41) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL1457414 | 0.86 | TACR1 (0.41) | TACR1MAPTP2RX7 | |
| SCHEMBL6410873 | 0.85 | ATM (0.43) | ALDH1A1ATM | |
| Hydrochloric Acid SCHEMBL6419339 | 0.84 | ATM (0.42) | ALDH1A1ATM | |
| Trifluoroacetic Acid SCHEMBL5120141 | 0.83 | SMN1; SMN2 (0.40) | SMN1; SMN2KMT2AMEN1TACR1ALDH1A1 | |
| SCHEMBL1457142 | 0.82 | EPHX2 (0.40) | KMT2AMEN1EPHX2 | |
| SCHEMBL1457277 | 0.77 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1EPHX2LMNA | |
| SCHEMBL1457432 | 0.76 | MEN1 (0.45) | SMN1; SMN2KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL1457735 | 0.76 | ALDH1A1 (0.41) | ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |
| EP-1893620-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006122769-A2 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF DRUGS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | disclosed |