Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 2/20 | 0.38 |
| ▸ | BECN1 | Q14457 | 2/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618111 | 0.77 | TTK (0.41) | MAPTSMN1; SMN2KMT2AMEN1TTK | |
| SCHEMBL14573283 | 0.73 | TTK (0.46) | MAPTLMNATP53TTKFGFR3 | |
| SCHEMBL4535523 | 0.73 | KMT2A (0.47) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL12271909 | 0.70 | FGFR3 (0.33) | ALDH1A1FGFR3KDR | |
| SCHEMBL17203013 | 0.69 | KMT2A (0.55) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL3573967 | 0.68 | MAPT (0.66) | MAPTSMN1; SMN2KMT2AMEN1GAA | |
| SCHEMBL4631425 | 0.67 | ALDH1A1 (0.56) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL12272621 | 0.66 | DYRK1A (0.39) | ALDH1A1FGFR3KDR | |
| SCHEMBL25296383 | 0.66 | SCD (0.46) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL1492829 | 0.66 | PORCN (0.73) | MAPTSMN1; SMN2KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |