Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.41 |
| ▸ | FLT3 | P36888 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573296 | 0.90 | TTK (0.43) | TTKFLT3ADORA3MAPTAURKA | |
| SCHEMBL14573297 | 0.86 | TTK (0.43) | TTKFLT3ADORA3AURKA | |
| SCHEMBL14573294 | 0.77 | TTK (0.50) | TTKFLT3AURKA | |
| SCHEMBL6366899 | 0.75 | TTK (0.45) | TTKFLT3AURKA | |
| SCHEMBL5619174 | 0.75 | TTK (0.53) | TTKFLT3GAA | |
| SCHEMBL5618421 | 0.74 | TTK (0.50) | TTKFLT3AURKA | |
| SCHEMBL14573293 | 0.74 | TTK (0.44) | TTKFLT3AURKA | |
| SCHEMBL5408049 | 0.74 | BACE1 (0.53) | TTKFLT3ADORA3MAPTIDO1 | |
| SCHEMBL12409312 | 0.72 | ADORA3 (0.56) | TTKFLT3ADORA3GAAMAPT | |
| SCHEMBL5618496 | 0.72 | TTK (0.54) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |