Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5412371 | 0.83 | CD274 (0.62) | CD274TTK | |
| SCHEMBL5618288 | 0.83 | MAPKAPK5 (0.55) | MAPKAPK5FYNFLT3ADORA3TTK | |
| SCHEMBL14573306 | 0.80 | AKT3 (0.44) | MAPKAPK5FLT3L3MBTL1TTK | |
| SCHEMBL5394670 | 0.78 | TTK (0.54) | MAPKAPK5FLT3CD274TTK | |
| SCHEMBL5405328 | 0.78 | CD274 (0.55) | CD274TTK | |
| SCHEMBL5617937 | 0.77 | FLT3 (0.47) | MAPKAPK5FLT3ADORA3TTK | |
| SCHEMBL5618395 | 0.77 | FLT3 (0.49) | MAPKAPK5FLT3ADORA3TTK | |
| SCHEMBL14573305 | 0.77 | KDM4E (0.55) | FLT3CD274TTK | |
| SCHEMBL5618766 | 0.76 | KDM4E (0.47) | MAPKAPK5FLT3ADORA3TTK | |
| SCHEMBL5404519 | 0.76 | EGFR (0.48) | FYNFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |