Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618652 | 0.95 | SYK (0.50) | KDM4EALDH1A1MAPTHSD17B10SYK | |
| SCHEMBL5619095 | 0.85 | FLT3 (0.49) | SYKFLT3 | |
| SCHEMBL5412371 | 0.84 | CD274 (0.62) | CD274TTK | |
| SCHEMBL14573304 | 0.83 | NR4A1 (0.42) | KDM4EFLT3TTK | |
| SCHEMBL5618420 | 0.80 | FLT3 (0.46) | FLT3TTK | |
| SCHEMBL5405328 | 0.79 | CD274 (0.55) | KDM4EALDH1A1CD274TTK | |
| SCHEMBL5394670 | 0.79 | TTK (0.54) | MAPTFLT3CD274TTK | |
| SCHEMBL5404519 | 0.78 | EGFR (0.48) | FLT3DYRK1A | |
| SCHEMBL5618409 | 0.77 | MMP13 (0.57) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL14573309 | 0.77 | MAPKAPK5 (0.50) | FLT3CD274TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |