Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.44 |
| ▸ | IKBKB | O14920 | 2/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573309 | 0.80 | MAPKAPK5 (0.50) | FLT3TTKMAPKAPK5L3MBTL1 | |
| SCHEMBL5618395 | 0.80 | FLT3 (0.49) | FLT3TTKMAPKAPK5 | |
| SCHEMBL5617937 | 0.78 | FLT3 (0.47) | FLT3TTKMAPKAPK5 | |
| SCHEMBL14573304 | 0.75 | NR4A1 (0.42) | CAMK2DFLT3TTK | |
| SCHEMBL5618766 | 0.73 | KDM4E (0.47) | FLT3TTKMAPKAPK5 | |
| SCHEMBL5618288 | 0.72 | MAPKAPK5 (0.55) | FLT3TTKMAPKAPK5 | |
| SCHEMBL5618824 | 0.71 | FLT3 (0.53) | IKBKBFLT3TTKMAPKAPK5L3MBTL1 | |
| SCHEMBL5575943 | 0.70 | CAMK2D (0.52) | IKBKBCAMK2DTTKLMNAKCNH2 | |
| SCHEMBL5618266 | 0.69 | L3MBTL3 (0.51) | IKBKBACKR3FLT3TTKMAPKAPK5 | |
| SCHEMBL5618106 | 0.69 | TTK (0.56) | FLT3TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |