Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 6/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.42 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | RBP4 | P02753 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457658 | 0.92 | MALT1 (0.51) | TRPA1P2RY12MALT1TRPV1RBP4 | |
| SCHEMBL1457425 | 0.92 | TRPV1 (0.45) | TRPA1MALT1TRPV1KCNH2TRPM8 | |
| SCHEMBL1457809 | 0.91 | TRPA1 (0.46) | TRPA1P2RY12MALT1TRPV1RBP4 | |
| SCHEMBL1457196 | 0.91 | MALT1 (0.43) | TRPA1MALT1TRPV1 | |
| SCHEMBL1457622 | 0.91 | TRPA1 (0.43) | TRPA1MALT1TRPV1KCNH2TRPM8 | |
| SCHEMBL1457623 | 0.91 | MALT1 (0.48) | TRPA1MALT1TRPV1KCNH2TRPM8 | |
| SCHEMBL1457328 | 0.91 | TRPA1 (0.41) | TRPA1MALT1TRPV1KCNH2TRPM8 | |
| SCHEMBL1456979 | 0.91 | TRPA1 (0.41) | TRPA1MALT1TRPV1KCNH2TRPM8 | |
| SCHEMBL1456790 | 0.90 | TRPA1 (0.42) | TRPA1MALT1TRPV1 | |
| SCHEMBL1457170 | 0.90 | RBP4 (0.41) | TRPA1MALT1TRPV1KCNH2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | claimed |
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |