Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.50 |
| ▸ | PDE4A | P27815 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.41 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.41 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6232036 | 0.90 | MEN1 (0.53) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL5359098 | 0.87 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL5359095 | 0.87 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6912242 | 0.86 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL6912241 | 0.86 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL5355223 | 0.85 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL5355215 | 0.85 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL5369892 | 0.84 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL5369901 | 0.84 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DGAA | |
| SCHEMBL498539 | 0.78 | ALDH1A1 (0.60) | PDE4BPDE4APDE4CPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |
| US-7176229-B2 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION (US) | 2007-02-13 | — | — | US | disclosed |