Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.51 |
| ▸ | PDE4A | P27815 | 6/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.50 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.50 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14575985 | 0.90 | PDE4B (0.50) | MEN1KMT2APOLBPDE4BPDE4A | |
| SCHEMBL6228920 | 0.85 | PDE4B (0.53) | MEN1KMT2APOLBPDE4BPDE4A | |
| SCHEMBL498265 | 0.82 | ALDH1A1 (0.69) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL5359098 | 0.81 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL5359095 | 0.81 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL7423087 | 0.80 | GAA (0.54) | MEN1KMT2APOLBPDE4BPDE4A | |
| SCHEMBL7418685 | 0.80 | GAA (0.54) | MEN1KMT2APOLBPDE4BPDE4A | |
| SCHEMBL5355215 | 0.80 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL5355223 | 0.80 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL5369892 | 0.79 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0933366-B1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-6235739-B1 | ANTIINFLAMMATORY AGENTS; ANTIHISTAMINES; SKIN DISORDERS | NIKKEN CHEMICALS CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0933366-A1 | 5-PHENYL-3-PYRIDAZINONE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-08-04 | — | — | EP | disclosed |