Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | CCR1 | P32246 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14577156 | 0.70 | CCR1 (0.44) | HPGDALDH1A1XDHCCR1CCR8 | |
| SCHEMBL14576626 | 0.69 | ALDH1A1 (0.42) | HPGDALDH1A1KDM4ECCR1CCR8 | |
| SCHEMBL14647508 | 0.68 | CCR1 (0.64) | CCR1CCR8METAP2TGFBR1 | |
| SCHEMBL30511194 | 0.65 | CCR1 (1.00) | HPGDALDH1A1KDM4ECCR1CCR8 | |
| SCHEMBL196966 | 0.65 | CCR1 (1.00) | HPGDALDH1A1KDM4ECCR1CCR8 | |
| SCHEMBL29388304 | 0.65 | CCR1 (1.00) | HPGDALDH1A1KDM4ECCR1CCR8 | |
| SCHEMBL20391837 | 0.64 | CCR1 (0.57) | XDHCCR1CCR8KMT2AMEN1 | |
| SCHEMBL20379821 | 0.64 | CCR1 (0.47) | ALDH1A1KDM4ECCR1CCR8SMN1; SMN2 | |
| SCHEMBL31678891 | 0.64 | CCR1 (0.47) | ALDH1A1KDM4ECCR1CCR8SMN1; SMN2 | |
| SCHEMBL28856048 | 0.64 | CCR1 (0.43) | HPGDALDH1A1KDM4ECCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155763-B2 | 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | TIUMBIO CO., LTD. (KR) | 2018-12-18 | — | — | US | disclosed |
| EP-2731949-B1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | TIUMBIO CO LTD (KR) | 2018-04-04 | — | — | EP | disclosed |
| EP-2731949-B1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | TIUMBIO CO LTD (KR) | 2018-04-04 | — | — | EP | disclosed |
| EP-2731949-A2 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | SK Chemicals Co., Ltd. (KR) | 2014-05-21 | — | — | EP | disclosed |
| US-20130018052-A1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | SK CHEMICALS CO., LTD. (KR) | 2013-01-17 | — | — | US | disclosed |
| US-20130018052-A1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | SK CHEMICALS CO., LTD. (KR) | 2013-01-17 | — | — | US | disclosed |
| US-20130018052-A1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | SK CHEMICALS CO., LTD. (KR) | 2013-01-17 | — | — | US | disclosed |
| WO-2013009140-A2 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | SK CHEMICALS CO., LTD. (KR) | 2013-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10155763-B2 | 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | ACVR1, ACVRL1, ALK | HPGD 3650/4885ALDH1A1 2182/4885KDM4E 336/4885 |
| US-20130018052-A1 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS | ACVR1, ACVRL1, ALK | HPGD 3650/4885ALDH1A1 2182/4885KDM4E 336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.