Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1457238 | 0.93 | ALDH1A1 (0.41) | KMT2AMEN1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1457159 | 0.93 | GAA (0.41) | KMT2AMEN1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1457551 | 0.93 | ALDH1A1 (0.41) | KMT2AMEN1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1457524 | 0.92 | ALDH1A1 (0.42) | KMT2AMEN1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1456891 | 0.92 | PDGFRB (0.41) | KMT2AMEN1GAAALDH1A1KDM4E | |
| SCHEMBL1457254 | 0.92 | LMNA (0.40) | KMT2AGAASMN1; SMN2ALDH1A1PDGFRB | |
| SCHEMBL1457496 | 0.90 | ALDH1A1 (0.45) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1457630 | 0.88 | SMN1; SMN2 (0.46) | KMT2AMEN1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL1457253 | 0.88 | ALDH1A1 (0.53) | KMT2AMEN1GAASMN1; SMN2ALDH1A1 | |
| SCHEMBL5119733 | 0.87 | KMT2A (0.46) | KMT2AMEN1GAASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | claimed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | claimed |
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |