Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TARS1 | P26639 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330431 | 0.84 | CYP2D6 (0.50) | CYP2D6CYP2C19MMP1MMP8ANPEP | |
| SCHEMBL3374178 | 0.84 | CYP2D6 (0.50) | CYP2D6CYP2C19MMP1MMP8ANPEP | |
| SCHEMBL14611659 | 0.83 | SPHK1 (0.38) | ANPEPDNPEPSPHK1TARS1CTSC | |
| Hydrochloric Acid SCHEMBL7328602 | 0.83 | CYP2D6 (0.48) | CYP2D6CYP2C19MMP1MMP8ANPEP | |
| Hydrochloric Acid SCHEMBL7328608 | 0.83 | CYP2D6 (0.48) | CYP2D6CYP2C19MMP1MMP8ANPEP | |
| SCHEMBL16151141 | 0.82 | GFPT1 (0.45) | — | |
| SCHEMBL22401380 | 0.82 | GFPT1 (0.45) | — | |
| SCHEMBL16151143 | 0.82 | GFPT1 (0.45) | — | |
| SCHEMBL28516179 | 0.82 | GFPT1 (0.45) | — | |
| SCHEMBL15941449 | 0.80 | SPHK1 (0.41) | MMP1MMP8ANPEPDNPEPSPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7183307-B2 | Pyrazole-derived kinase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCROPORATED (US) | 2007-02-27 | — | — | US | disclosed |