SCHEMBL1457797

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1458314	0.91	KMT2A (0.48)	TTRKMT2ATPMTRORCCA12
	SCHEMBL1459275	0.85	TPMT (0.50)	TTRKMT2ATPMTRORCPOLB
	SCHEMBL1458167	0.83	CA12 (0.50)	KMT2ARORCCA12CA1CA2
	SCHEMBL1458211	0.82	TPMT (0.59)	TTRKMT2ATPMTPOLBCA12
	SCHEMBL1573045	0.80	TPMT (0.56)	TTRKMT2ATPMTPOLBMEN1
	SCHEMBL4907208	0.80	CA12 (0.60)	TTRTPMTPOLBCA12CA1
	SCHEMBL15658321	0.79	TSHR (0.53)	TTRKMT2ATPMTRORCCA12
	SCHEMBL403840	0.79	RORC (0.56)	TTRKMT2ATPMTRORCPOLB
	SCHEMBL1458531	0.78	KMT2A (0.50)	KMT2ATPMTCA12CA1CA2
	SCHEMBL1458440	0.77	KMT2A (0.48)	KMT2ATPMTCA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.