SCHEMBL1458

SCHEMBL1458

Cc1noc(-c2ccc(Br)cc2)c1CC=CCc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.40
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
RAB9A P51151 3/20 0.36
SMN1; SMN2 Q16637 3/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
LMNA P02545 2/20 0.36
NR1H4 Q96RI1 1/20 0.36
MAPT P10636 3/20 0.36
NPC1 O15118 2/20 0.36
POLB P06746 1/20 0.36
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
HDAC1 Q13547 1/20 0.34
ALDH1A1 P00352 3/20 0.33
GAA P10253 2/20 0.33
GALR3 O60755 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1300 0.79 CYP1A2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL6464 0.79 MEN1 (0.55) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1240 0.79 CYP1A2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL18597812 0.78 CYP1A2 (0.44) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL7164 0.77 LPAR1 (0.51) CYP2C9SMN1; SMN2L3MBTL1NR1H4MAPT
SCHEMBL7280 0.77 LPAR1 (0.51) CYP2C9SMN1; SMN2L3MBTL1NR1H4MAPT
SCHEMBL1593 0.77 LPAR1 (0.51) CYP2C9SMN1; SMN2L3MBTL1NR1H4MAPT
SCHEMBL6841 0.77 CYP1A2 (0.38) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL18597777 0.76 ALDH1A1 (0.44) CYP1A2CYP3A4CYP2C9CYP2C19TDP1
SCHEMBL1347 0.76 KMT2A (0.43) SMN1; SMN2MAPTPOLBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483251-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483253-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041729-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041462-A2 POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed